<!DOCTYPE html>
<html lang="en">
<head>
    <meta charset="UTF-8">
    <meta name="viewport" content="width=device-width, initial-scale=1.0">
    <meta http-equiv="X-UA-Compatible" content="ie=edge">
    <title>Document</title>
    <style>
        *{margin:0;padding:0;}
        #content{
            width:1000px;
            display:flex;
            margin:0 auto;
            flex-wrap:wrap;
        }
        #content>div{
            background:#ddd;
            margin-bottom:5px;

        }
        #content>div:first-child
        {
            width: 610px;height:377px;
            margin-left:10px;
            position: relative;
        }
        #content>div:nth-child(2)
        {
            width: 381px;height:377px;
        }
        #content>div:nth-child(3)
        {
            width: 377px;height:235px;
            margin-left:10px;
            position: relative;
        }
        #content>div.product
        {
            width: 198px;height:235px;
            position: relative;
        }
        div.product+div.product{
            margin-left:10px;
        }
        
    </style>
</head>
<body>
    <div id="content">
        <div></div>
        <div></div>
        <div></div>
        <div class="product"></div>
        <div class="product"></div>
        <div class="product"></div>
    </div>
    
</body>
</html>